Detailed view for TVAG_285090

Basic information

TDR Targets ID: 925891
Trichomonas vaginalis, myst histone acetyltransferase, putative
Source Database / ID: 

pI: 7.878 | Length (AA): 364 | MW (Da): 42474 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01853   MOZ/SAS family
PF11717   RNA binding activity-knot of a chromodomain

Gene Ontology

Mouse over links to read term descriptions.
GO:0072487   GO:MSL complex  

GO:0016573   histone acetylation  
GO:0006355   regulation of transcription, DNA-dependent  
GO:0004402   histone acetyltransferase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131853)

Species Accession Gene Product
Brugia malayi Bm1_08860   MOZ/SAS family protein
Drosophila melanogaster Dmel_CG11290   enoki mushroom
Echinococcus granulosus EgrG_000171900   histone acetyltransferase myst4
Echinococcus multilocularis EmuJ_000171900   histone acetyltransferase myst4
Homo sapiens ENSG00000083168   K(lysine) acetyltransferase 6A
Homo sapiens ENSG00000156650   K(lysine) acetyltransferase 6B
Loa Loa (eye worm) LOAG_06919   hypothetical protein
Mus musculus ENSMUSG00000021767   K(lysine) acetyltransferase 6B
Mus musculus ENSMUSG00000031540   K(lysine) acetyltransferase 6A
Schmidtea mediterranea mk4.002285.03   Putative myst histone acetyltransferase
Trichomonas vaginalis TVAG_285090   myst histone acetyltransferase, putative
Trichomonas vaginalis TVAG_408380   mst1, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_285090 (Trichomonas vaginalis), myst histone acetyltransferase, putative
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